Slide2

Reduction in Cost of Care

Huston RK, et al. "Decreasing Necrotizing Enterocolitis and Gastrointestinal Bleeding in the Neonatal Intensive Care Unit: The Role of Donor Human Milk and Exclusive Human Milk Diet in Infants Less 1500 g birth weight.ICAN: Adult Child and Adolescent Nutrition. 20 August 2013. 13:127. doi: 10.1186/1471-2431-13-127

 

Ganapathy V, et al. “Costs of Necrotizing Enterocolitis and Cost-Effectiveness of Exclusively Human Milk-Based Products in Feeding Extremely Premature Infants.” Breastfeeding Medicine. February 2012. 7(1):29-37. doi: 10.1089/bfm.2011.0002.

 

Assad M, et al. "Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet."  Journal of Perinatology. 12 November 2015. doi: 10.1038/jp.2015.168.

 

Reduction of NEC (Necrotizing Enterocolitis)

 

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet."  Breastfeeding Medicine. March 2016. 11(2): 70-74. doi:10.1089/bfm.2015.0134.

 

Assad M, et al. "Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet."  Journal of Perinatology. 12 November 2015. doi: 10.1038/jp.2015.168.

Hermann K, et al. “An Exclusively Human Milk Diet Reduces Necrotizing Enterocolitis.” Breastfeeding Medicine. May 2014.  9(4): 184–190. doi: 10.1089/bfm.2013.0121

Cristofalo EA, et al. “An Exclusively Human Milk Diet Reduces Necrotizing Enterocolitis.” The Journal of Pediatrics. December 2013. 163 (6):1592-1595. doi: 10.1016/j.jpeds.2013.07.011

Hair A, et al. "Human milk feeding supports adequate growth in infants < 1250 grams birth weight." BMC Research Notes. 13 November 2013. doi: 10.1186/1756-0500-6-459

Huston RK, et al. "Decreasing Necrotizing Enterocolitis and Gastrointestinal Bleeding in the Neonatal Intensive Care Unit: The Role of Donor Human Milk and Exclusive Human Milk Diet in Infants Less <= to 1500 g birth weight.ICAN: Adult Child and Adolescent Nutrition. 20 August 2013. 13:127. doi: 10.1186/1471-2431-13-127

 

Sullivan S, et al. “An exclusively human milk-based diet is associated with a lower rate of necrotizing enterocolitis than a diet of human milk and bovine milk-based products.” The Journal of Pediatrics 2010. doi: 10.1016/j.jpeds.2009.10.040.

 

Reduction of TPN Use (Total Parental Nutrition)

Cristofalo EA, et al. “Randomized Trial of Exclusive Human Milk versus Preterm Formula Diets in Extremely Premature Infants.” The Journal of Pediatrics. December 2013. 163(6):1592-1595. doi: 10.1016/j.jpeds.2013.07.011

 

Ghandehari H, et al.“An Exclusive Human Milk-Based Diet in Extremely Premature Infants Reduces the Probability of Remaining on Total Parenteral Nutrition: A reanalysis of the data.”  BMC Pediatrics. 2012. 5: 188. doi:10.1186/1756-0500-5-188.

 

Flexibility of Feeding

Guidelines for Acute Care of the Neonate (24th Edition). Texas Children/Baylor College. 2016.

 

Abrams SA, et al. “Greater mortality and morbidity in extremely preterm infants fed a diet containing cow milk protein products.”  Breastfeeding Medicine. June 2014. 9(6): 281-0285. doi:10.1089/bfm.2014.0024.

 

Hair A, et al. "Human milk feeding supports adequate growth in infants < 1250 grams birth weight." BMC Research Notes. 13 November 2013. doi: 10.1186/1756-0500-6-459

 

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet."  Breastfeeding Medicine. March 2016. 11(2): 70-74. doi:10.1089/bfm.2015.0134.

Tabata M, et al. "Fortifier and Cream Improve Fat Delivery in Continuous Enteral Infant Feeding of Breast Milk. Nutrients. 11 February 2015. 7(2): 1174-1183. doi:10.3390/nu7021174.

 

Late Onset of Sepsis

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet."  Breastfeeding Medicine. March 2016. 11(2): 70-74. doi:10.1089/bfm.2015.0134.

 

Retinopathy of Prematurity (ROP)

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet."  Breastfeeding Medicine. March 2016. 11(2): 70-74. doi:10.1089/bfm.2015.0134.

 

Feeding Intolerance

Assad M, et al. "Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet."  Journal of Perinatology. 12 November 2015. doi: 10.1038/jp.2015.168.

 

Mortality

Assad M, et al. "Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet."  Journal of Perinatology. 12 November 2015. doi: 10.1038/jp.2015.168.

 

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet."  Breastfeeding Medicine. March 2016. 11(2): 70-74. doi:10.1089/bfm.2015.0134.

 
Abrams SA, et al. “Greater mortality and morbidity in extremely preterm infants fed a diet containing cow milk protein products.”  Breastfeeding Medicine. June 2014. 9(6): 281-0285. doi:10.1089/bfm.2014.0024.

Ventilation Days

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet."  Breastfeeding Medicine. March 2016. 11(2): 70-74. doi:10.1089/bfm.2015.0134.

 

Decreased Length of Stay in the NICU

Hair A, et al. "Premature Infants 750–1,250 g Birth Weight Supplemented with a Novel Human Milk-Derived Cream Are Discharged Sooner  Breastfeeding Medicine. April 2016. doi:10.1089/bfm.2015.0166.

Clinical Studies on Prolact CR

Hair A, et al. "Premature Infants 750–1,250 g Birth Weight Supplemented with a Novel Human Milk-Derived Cream Are Discharged Sooner  Breastfeeding Medicine. April 2016. doi:10.1089/bfm.2015.0166.
 

Tabata M, et al. "Fortifier and Cream Improve Fat Delivery in Continuous Enteral Infant Feeding of Breast Milk  Nutrients February 2015. doi:10.3390/nu7021174.


Hair A, et al. "Randomized Trial of Human Milk Cream as a Supplement to Standard Fortification of an Exclusive Human Milk-Based Diet in Infants 750-1250 g Birth Weight  J. Peds November 2014.

Additional Publications

Extramural Published Papers of Interest

Bloom B. "Safety of donor milk: a brief report.Journal of Perinatology. May 2016. 392-393. doi:10.1038/jp.2015.207.

 

Goldstein M. "The Value of Human Milk Access for Premature Infants."  Institute for Patient Access. December 2015.

 

Assad M, et al. "Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet."  Journal of Perinatology. 12 November 2015. doi: 10.1038/jp.2015.168.

 

Johnson TJ, et al. "Economic Benefits and Costs of Human Milk Feedings: A Strategy to Reduce the Risk of Prematurity-Related Morbidities in Very-Low-Birth-Weight Infants."  Nutrients. March 2014. 5: 207-212. doi: 10.3945/ an.113.004788.

 

Hair A, et al. "Human milk feeding supports adequate growth in infants < 1250 grams birth weight." BMC Research Notes. 13 November 2013. doi: 10.1186/1756-0500-6-459

 

Herrmann K, et al. "An Exclusively Human Milk Diet Reduces Necrotizing Enterocolitis." Breastfeeding Medicine. 1 May 2014. 9(4): 184-190. doi: 10.1089/bfm.2013.0121

 

Huston RK, et al. "Decreasing Necrotizing Enterocolitis and Gastrointestinal Bleeding in the Neonatal Intensive Care Unit: The Role of Donor Human Milk and Exclusive Human Milk Diet in Infants Less <= to 1500 g birth weight.ICAN: Adult Child and Adolescent Nutrition. 20 August 2013. 13:127. doi: 10.1186/1471-2431-13-127

 

Bertino E, et al. "Benefits of donor milk in the feeding of preterm infants." Early Human Development. October 2013. 89 Suppl 2: S3-6. doi: 10.1016/j.earlhumdev.2013.07.008.

 

Patel AL, et al. "Impact of Early Human Milk on Sepsis and Health Care Costs in Very Low Birth Weight Infants.Journal of Perinatology. July 2013. 33(7):514-9. doi: 10.1038/jp.2013.2.

 

Underwood MA. "Human milk for the premature infant.Pediatric Clinics of North America. February 2013. 60(1):189-207. doi:10.1016/j.pcl.2012.09.008.

 

Policy Statement from the American Academy of Pediatrics. “Breastfeeding and the Use of Human Milk.” Pediatrics. 2012. 7(1):29-37. doi: 10.1542/peds.2011-3552.

 

Hicks PD, et al. "Calcium absorption in very low birth weight infants with and without bronchopulmonary dysplasia.The Journal of Pediatrics. June 2011. 158(6):885-890.e1. doi: 10.1016/j.jpeds.2010.12.034.

 

Meier PP, et al.. "Improving the Use of Human Milk During and After the NICU Stay." Clinics in Perinatology. March 2010. 37(1):217-45. doi: 10.1016/j.clp.2010.01.013.

 

Rogers SP, et al. "Continuous feedings of fortified human milk lead to nutrient losses of fat, calcium and phosphorous.Nutrients. Mar 2010. 2(3):230-40. doi: 10.3390/nu2030240.

 

Bhatia J. "Human milk and the premature infant." Journal of Perinatology. 2007. 27: S71–S74. doi:10.1038/sj.jp.7211713.

 

Boyd CA, et al. "Donor breast milk versus infant formula for preterm infants: systematic review and meta-analysis.ADC Fetal and Neonatal Edition. 2007. 92:3 F158-F159. doi:10.1136/adc.2005.089490.

 

Bell EF. "Preventing necrotizing enterocolitis: what works and how safe?Pediatrics. January 2005. 115(1):173-4. doi: 10.1542/peds.2004-2360.

 

Schanler RJ, et al. "Randomized trial of donor human milk versus preterm formula as substitutes for mothers' own milk in the feeding of extremely premature infants." Pediatrics. August 2005. 116(2):400-6. doi: 10.1542/peds.2004-1974.

 

McGuire W, Anthony MY. "Donor human milk versus formula for preventing necrotizing enterocolitis in preterm infants: systematic review." ADC Fetal and Neonatal Edition. 2003. 88: F11-F14.

 

Bisquera JA, et al. "Impact of Necrotizing Enterocolitis on Length of Stay and Hospital Charges in Very Low Birth Weight Infants." Pediatrics. March 2002. 109(3):423-8. doi:10.1542/peds.109.3.423.

 

Hanson LA, et al. "The role of breastfeeding in the prevention of neonatal infection.Seminars in Fetal and Neonatal. 2002. 7: 275-281. doi: http://dx.doi.org/10.1053/siny.2002.0124.

 

Kosloske AM. "Breast Milk Decreases the Risk of Neonatal Necrotizing Enterocolitis." Advances in Nutritional Research. 2001. 6: 123-137. doi: 10.1007/978-1-4615-0661-4_6.

 

Schanler RJ, et al. "The use of human milk and breastfeeding in premature infants." Clinics in Perinatology. 1999. 26; 370-398.

 

Lucas A, et al. "Randomised trial of early diet in preterm babies and later intelligence quotient." BMJ. 28 Nov 1998. 317(7171): 1481–1487. doi: http://dx.doi.org/10.1136/bmj.317.7171.1481.

 

Schanler RJ. "Fortified human milk: nature's way to feed premature infants."BMJ. March 1998. 14(1):5-11.
 

El-Mohandes AE, et al. "Use of Human milk in intensive care nursery decreases the incidence of nosocomial sepsis." Journal of Perinatology. 1997. 17: 30-34.

 

Lucas A, et al. "Randomized outcome trial of human milk fortification and developmental outcome in preterm infants." American Journal of Clinical Nutrition. August 1996. 64(2):142-51.

 

Wang Y, et al. "The effect of exclusive breastfeeding on development and incidence of infections in infants." Journal of Human Lactation. 1996. 12: 27. doi: 10.1177/089033449601200107.

 

Dewey K, et al. "Differences in morbidity between breast-fed and formula-fed infants." The Journal of Pediatrics. 1995. 126:696. doi: http://dx.doi.org/10.1016/S0022-3476(95)70395-0.

 

Lucas A, et al. "Breast milk and neonatal necrotising enterocolitis."Lancet. Dec 22 1990. 336(8730): 1519-23.

 

Cochi S, et al. "Primary invasive Haemophilus influenzae type b disease: a population-based assessment of risk factors." Journal of Perinatology. June 1986: 108(6):887-96.

 

Narayanan I, et al. "Randomised controlled trial of effect of raw and holder pasteurised human milk and of formula supplements on incidence of neonatal infection." Lancet. Nov 17 1984. 2(8412): 1111-3. doi: http://dx.doi.org/10.1016/S0140-6736(84)91554-X.

 

Narayanan I, et al. "The value of human milk in the prevention of infection in the high-risk low-birth-weight infant." The Journal of Pediatrics. Sep 1981. 99(3):496-8. doi: http://dx.doi.org/10.1016/S0022-3476(81)80360-5.

 

Narayanan I, et al. "Partial supplementation with expressed breast-milk for prevention of infection in low-birth-weight infants." Lancet. Sep 13 1980. 2(8194):561-3. doi: http://dx.doi.org/10.1016/S0140-6736(80)91994-7.

 

Prolacta Bioscience Published Papers

Abrams SA, et al. “Greater mortality and morbidity in extremely preterm infants fed a diet containing cow milk protein products.”  Breastfeeding Medicine. August 2014, 9(6): 281-285. doi: 10.1089/bfm.2014.0024.

 

Ganapathy V, et al. “Long term healthcare costs of infants who survived neonatal necrotizing enterocolitis: a retrospective longitudinal study among infants enrolled in Texas Medicaid.” BMC Pediatrics. 2013, 13:127. doi: 10.1186/1471-2431-13-127.

 

Ghandehari H, et al.“An Exclusive Human Milk-Based Diet in Extremely Premature Infants Reduces the Probability of Remaining on Total Parenteral Nutrition: A reanalysis of the data.”  BMC Pediatrics. 2012. 5: 188. doi:10.1186/1756-0500-5-188.

 

Sullivan S, et al. “An exclusively human milk-based diet is associated with a lower rate of necrotizing enterocolitis than a diet of human milk and bovine milk-based products.The Journal of Pediatrics 2010. doi: 10.1016/j.jpeds.2009.10.040.

 

Wojcik KY, et al. “Macronutrient analysis of a nationwide sample of donor breast milk.” Journal of the American Dietetic Association. 2009. 109: 137-140.

 

Chan GM, et al. “Effects of a human-milk derived human milk fortifier on the antibacterial actions of human milk.” Breastfeeding Medicine. 2007. 2(4): 205-208. doi:10.1089/bfm.2007.0015.

 

Terpstra FG, et al. “Antimicrobial and antiviral effect of high-temperature short-time pasteurization applied to human milk.”  Breastfeeding Medicine. 2007. 2(1) 27-33. doi:10.1089/bfm.2006.0015.

 

Lee ML. “The Design and analysis of studies in premature infants using human donor milk or preterm formula as primary nutrition: milk.” Breastfeeding Medicine. 2006. 1(2): 88-93. doi:10.1089/bfm.2006.1.88.

 

Rechtman DJ, et al. Effect of environmental conditions on unpasteurized donor human milk”. Breastfeeding Medicine. 2006. 1(1): 24-26. doi:10.1089/bfm.2006.1.24.

 

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