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Research and Publications

 

Reduction in Cost of Care

Hampson G, Roberts SLE, Lucas A, Parkin D. An economic analysis of human milk supplementation for very low birth weight babies in the USABMC Pediatrics. 2019 doi:10.1186/s12887-019-1691-4

Assad M, Elliott MJ, Abraham JH. Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet. J Perinatol. 2016;36(3):216-220. doi:10.1038/jp.2015.168

Ganapathy V, Hay JW, Kim JH. Costs of necrotizing enterocolitis and cost-effectiveness of exclusively human milk-based products in feeding extremely premature infants. Breastfeed Med. 2012;7(1):29-37. doi:10.1089/bfm.2011.0002

Huston RK, Markell AM, McCulley EA, et al.
 Decreasing necrotizing enterocolitis and gastrointestinal bleeding in the neonatal intensive care unit: the role of donor human milk and exclusive human milk diets in infants ≤ 1500 g birth weight. ICAN: Adult Child and Adolescent Nutrition. 2013;13:127. doi:10.1177/1941406413519267
 

  
 

Reduction of NEC (Necrotizing Enterocolitis)

Huston RK, Markell AM, McCulley EA, Gardiner SK, Sweeney SL. Improving growth for infants ≤ 1250 grams receiving an exclusive human milk diet. Nutr Clin Pract. 2018;33(5):671-678. doi:10.1002/ncp.10054


Hair AB, Peluso AM, Hawthorne KM, et al. Beyond necrotizing enterocolitis prevention: improving outcomes with an exclusive human milk-based diet. Breastfeed Med. 2016;11(2):70-74. doi:10.1089/bfm.2015.0134

Assad M, Elliott MJ, Abraham JH. Decreased cost and improved feeding tolerance in VBLW infants fed an exclusive human milk diet. J Perinatol. 2016;36(3):216-220. doi:10.1038/jp.2015.168
 

Hermann K, Carroll K. An exclusively human milk diet reduces necrotizing enterocolitis. Breastfeed Med. 2014;9(4):184-190. doi:10.1089/bfm.2013.0121

Cristofalo EA, Schanler RJ, Blanco CL, et al. Randomized trial of exclusive human milk versus preterm formula diets in extremely premature infants. J Pediatr. 2013;163(6):1592-1595. doi:10.1016/j.jpeds.2013.07.011

Hair AB, Hawthorne KM, Chetta KE, Abrams SA. Human milk feeding supports adequate growth in infants ≤ 1250 grams birth weight. BMC Res Notes. 2013;6:459. doi:10.1186/1756-0500-6-459

Huston RK, Markell AM, McCulley EA, et al. Decreasing necrotizing enterocolitis and gastrointestinal bleeding in the neonatal intensive care unit: the role of donor human milk and exclusive human milk diets in infants ≤ 1500 g birth weight. ICAN: Adult Child and Adolescent Nutrition. 2013;13:127. doi:10.1177/1941406413519267

Sullivan S, Schanler RJ, Kim JH, et al. An exclusively human milk-based diet is associated with a lower rate of necrotizing enterocolitis than a diet of human milk and bovine milk-based products. J Pediatr. 2010;156(4):562-567. doi:10.1016/j.jpeds.2009.10.040


Growth

Visuthranukul C, Abrams SA, Hawthorne KM, Hagan KL, Hair AB. Premature small for gestational age infants fed an exclusive human milk-based diet achieve catch-up growth without metabolic consequences at 2 years of age. 2019;104(3):F242-F247. doi:10.1136/archdischild-2017-314547


Sandhu A, Fast S, Bonnar K, Baier RJ, Narvey M. Human-based human milk fortifier as rescue therapy in very low birth weight infants demonstrating intolerance to bovine-based human milk fortifier. 2017;12(9):570-573. doi:10.1089/bfm.2017.0017

Huston RK, Markell AM, McCulley EA, Gardiner SK, Sweeney SL. Improving growth for infants ≤ 1250 grams receiving an exclusive human milk diet. Nutr Clin Pract. 2018;33(5):671-678. doi:10.1002/ncp.10054

Hair AB, Peluso AM, Hawthorne KM, et al. Beyond necrotizing enterocolitis prevention: improving outcomes with an exclusive human milk-based diet. Breastfeed Med. 2016;11(2):70-74. doi:10.1089/bfm.2015.0134

Hair AB, Hawthorne KM, Chetta KE, Abrams SA. Human milk feeding supports adequate growth in infants ≤ 1250 grams birth weight. BMC Res Notes. 2013;6:459. doi:10.1186/1756-0500-6-459


Reduction of TPN Use (Total Parental Nutrition)

Hair AB, Rechtman DJ, Lee ML, Niklas V. Beyond necrotizing enterocolitis: other clinical advantages of an exclusive human milk diet. Breastfeed Mag. 2018;13(6):408-411. doi:10.1089/bfm.2017.0192

Cristofalo EA, Schlaner RJ, Blanco CL, et al. Randomized trial of exclusive human milk versus preterm formula diets in extremely premature infants. J Pediatr. 2013;163(6):1592-1595. doi:10.1016/j.jpeds.2013.07.011

Ghandehari H, Lee ML, Rechtman DJ, H2MF Study Group. An exclusive human milk-based diet in extremely premature infants reduces the probability of remaining on total parenteral nutrition: a reanalysis of the data. BMC Res Notes. 2012;5:188. doi:10.1186/1756-0500-5-188
 

Flexibility of Feeding

Sandhu A, Fast S, Bonnar K, Baier RJ, Narvey M. Human-Based Human Milk Fortifier as Rescue Therapy in Very Low Birth Weight Infants Demonstrating Intolerance to Bovine-Based Human Milk FortifierBreastfeed Med. 2017;12(9):570–573. doi:10.1089/bfm.2017.0017


Baylor College of Medicine. Guidelines for acute care of the neonate (24th Edition). 2016.
 

Abrams SA, Schanler RJ, Lee ML, Rechtman DJ. Greater mortality and morbidity in extremely preterm infants fed a diet containing cow milk protein products. Breastfeed Med. 2014;9(6):281-285. doi:10.1089/bfm.2014.0024

 

Hair AB, Hawthorne KM, Chetta KE, Abrams SA. Human milk feeding supports adequate growth in infants ≤ 1250 grams birth weight. BMC Res Notes. 2013;6:459. doi:10.1186/1756-0500-6-459

Hair AB, Peluso AM, Hawthorne KM, et al. Beyond necrotizing enterocolitis prevention: improving outcomes with an exclusive human milk-based diet. Breastfeed Med. 2016;11(2):70-74. doi:10.1089/bfm.2015.0134

Tabata M, Abdelrahman K, Hair AB, Hawthorne KM, Chen Z, Abrams SA. Fortifier and cream improve fat delivery in continuous enteral infant feeding of breast milk. Nutrients. 2015;7(2):1174-1183. doi:10.3390/nu7021174
 

Late Onset of Sepsis

Hair AB, Peluso AM, Hawthorne KM, et al. Beyond necrotizing enterocolitis prevention: improving outcomes with an exclusive human milk-based dietBreastfeed Med. 2016;11(2):70-74. doi:10.1089/bfm.2015.0134

 


Retinopathy of Prematurity (ROP)

Hair AB, Peluso AM, Hawthorne KM, et al. Beyond necrotizing enterocolitis prevention: improving outcomes with an exclusive human milk-based dietBreastfeed Med. 2016;11(2):70-74. doi:10.1089/bfm.2015.0134

 


Feeding Intolerance

Sandhu A, Fast S, Bonnar K, Baier RJ, Narvey M. Human-Based Human Milk Fortifier as Rescue Therapy in Very Low Birth Weight Infants Demonstrating Intolerance to Bovine-Based Human Milk FortifierBreastfeed Med. 2017;12(9):570–573. doi:10.1089/bfm.2017.0017

Assad M, Elliott MJ, Abraham JH. Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet. J Perinatol. 2016;36(3):216-220. doi:10.1038/jp.2015.168

 

Mortality

Assad M, Elliott MJ, Abraham JH. Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk dietJ Perinatol. 2016;36(3):216-220. doi:10.1038/jp.2015.168
 

Hair AB, Peluso AM, Hawthorne KM, et al. Beyond necrotizing enterocolitis prevention: improving outcomes with an exclusive human milk-based dietBreastfeed Med. 2016;11(2):70-74. doi:10.1089/bfm.2015.0134  
 

Abrams SA, Schanler RJ, Lee ML, Rechtman DJ. Greater mortality in extremely preterm infants fed a diet containing cow milk protein products. Breastfeed Med. 2014;9(6):281-285. doi:10.1089/bfm.2014.0024 



 

Ventilation Days

Hair AB, Peluso AM, Hawthorne KM, et al. Beyond necrotizing enterocolitis prevention: improving outcomes with an exclusive human milk-based dietBreastfeed Med. 2016;11(2):70-74. doi:10.1089/bfm.2015.0134  

 


Decreased Length of Stay in the NICU

Hair AB, Bergner EM, Lee ML, et al. Premature infants 750-1250 g birth weight supplemented with a novel human milk-derived cream are discharged sooner. Breastfeed Med. 2016;11:133-137. doi:10.1089/bfm.2015.0166
 


Clinical Studies on Prolact CR

Hair AB, Bergner EM, Lee ML, et al. Premature infants 750-1250 g birth weight supplemented with a novel human milk-derived cream are discharged sooner. Breastfeed Med. 2016;11:133-137. doi:10.1089/bfm.2015.0166

Tabata M, Abdelrahman K, Hair AB, Hawthorne KM, Chen Z, Abrams SA. Fortifier and cream improve fat delivery in continuous enteral infant feeding of breast milk. Nutrients. 2015;7(2):1174-1183. doi:10.3390/nu7021174
 

Hair AB, Blanco CL, Moreira AG, et al. Randomized trial of human milk cream as supplement to standard fortification of an exclusive human milk-based diet in infants 750-1250 g birth weight. J Pediatr. 2014;165(5):915-920. doi:10.1016/j.jpeds.2014.07.005

 

Additional Publications

Extramural Published Papers of Interest

 

Salcedo J, Karav S, Le Parc A, et al. Application of industrial treatments to donor human milk: influence of pasteurization treatments, storage temperature, and time on human milk gangliosides. NPJ Sci Food. 2018;2:5. doi:10.1038/s41538-018-0013-9

Bloom BT. Safety of donor milk: a brief report. J Perinatol. 2016;36(5):392-393. doi:10.1038/jp.2015.207
 

Goldstein M. Institute for Patient Access. The value of human milk access for premature infants 2015

  

Johnson TJ, Patel AL, Bigger HR, Engstrom JL, Meier PP. Economic benefits and costs of human milk feedings: a strategy to reduce the risk of prematurity-related morbidities in very-low-birth-weight infants. Adv Nutr. 2014;5(2):207-212. doi:10.3945/an.113.004788

 

Bertino E, Giuliani F, Baricco M, et al. Benefits of donor milk in the feeding of preterm infants. Early Hum Dev. 2013;89 Suppl 2:S3-6. doi:10.1016/j.earlhumdev.2013.07.008

Patel AL, Johnson TJ, Engstrom JL, et al. Impact of early human milk on sepsis and health-care costs in very low birth weight infants. J Perinatol. 2013;33(7):514-519. doi:10.1038/jp.2013.2
 

Underwood MA. Human milk for the premature infant. Pediatr Clin North Am. 2013;60(1):189-207. doi:10.1016/j.pcl.2012.09.008


Section on Breastfeeding. Breastfeeding and the use of human milk. Pediatrics. 2012;129(3):e827-841. doi:10.1542/peds.2011-3552
 

Hicks PD, Rogers SP, Hawthorne KM, Chen Z, Abrams SA. Calcium absorption in very low birth weight infants with and without bronchopulmonary dysplasia. J Pediatr. 2011;158(6):885-890. doi:10.1016/j.jpeds.2010.12.034
 

Meier PP, Engstrom JL, Patel AL, Jegier BJ, Bruns NE. Improving the use of human milk during and after the NICU stay. Clin Perinatol. 2010;37(1):217-245. doi:10.1016/j.clp.2010.01.013
 

Rogers SP, Hicks PD, Hamzo M, Veit LE, Abrams SA. Continuous feedings of fortified human milk lead to nutrient losses of fat, calcium, and phosphorous. Nutrients. 2010;2(3):230-240. doi:10.3390/nu2030240
 

Bhatia J. Human milk and the premature infant. Ann Nutr Metab. 2013;62 Suppl 3:8-14. doi:10.1159/000351537


Boyd CA, Quigley MA, Brocklehurst P. Donor breast milk versus infant formula for preterm infants: systemic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed. 2007;92(3):F158-F159. doi:10.1136/adc.2005.089490

 

Bell EF. Preventing necrotizing enterocolitis: what works and how safe?. Pediatrics. 2005;115(1):173-174. doi:10.1542/peds.2004-2360
 

Schanler RJ, Lau C, Hurst NM, Smith EO. Randomized trial of donor human milk versus preterm formula as substitutes for mother’s own milk in the feeding of extremely premature infants. Pediatrics. 2005;116(2):400-406. doi:10.1542/peds.2004-1974

McGuire W, Anthony MY. Donor human milk versus formula for preventing necrotizing enterocolitis in preterm infants: systematic review. Arch Dis Child Fetal Neonatal Ed. 2003;88(1):F11-F14. doi:10.1136/fn.88.1.f11
 

Bisquera JA, Cooper TR, Berseth CL. Impact of necrotizing enterocolitis on length of stay and hospital charges in very low birth weight infants. Pediatrics. 2002;109(3):423-428. doi:10.1542/peds.109.3.423

Hanson LA, Korotkova M. The role of breastfeeding in prevention of neonatal infection. Semin Neonatol. 2002;7(4):275-281. doi:10.1053/siny.2002.0124
 

Kosloske AM. Breast milk decreases the risk of neonatal necrotizing enterocolitis. Adv Nutr Res. 2001;10:123-137. doi:10.1007/978-1-4615-0661-4_6

Schanler RJ, Hurst NM, Lau C. The use of human milk and breastfeeding in premature infants. Clin Perinatol. 1999;26(2):370-398.
 

Lucas A, Morley R, Cole TJ. Randomised trial of early diet in preterm babies and later intelligence quotient. BMJ. 1998;317(7171):1481-1487. doi:10.1136/bmj.317.7171.1481

Schanler RJ. Fortified human milk: nature’s way to feed premature infants. J Hum Lact. 1998;14(1):5-11. doi:10.1177/089033449801400104

 

El-Mohandes AE, Picard MB, Simmens SJ, Keiser JF. Use of human milk in the intensive care nursery decreases the incidence of nosocomial sepsis. J Perinatol. 1997;17(2):130-134.https://www.ncbi.nlm.nih.gov/pubmed/9134512. Accessed September 1, 2019.

Lucas A, Fewtrell MS, Morley R, et al. Randomized outcome trial of human milk fortification and developmental outcome in preterm infants. AM J Clin Nutr. 1996;64(2): 142-151. doi:10.1093/acjn/64.2.142


Wang YS, Wu SY. The effect of exclusive breastfeeding on development and incidence of infection in infants. J Hum Lact. 1996;12(1):27-30. doi:10.1177/089033449601200107
 

Dewey KG, Heinig MJ, Nommsen-Rivers LA. Differences in morbidity between breast-fed and formula-fed infants. J Pediatr. 1995;126(5 Pt 1):696-702. doi:10.1016/s0022-3476(95)70395-0

Lucas A, Cole TJ. Breast milk and neonatal necrotising enterocolitis. Lancet. 1990;336(8730):1519-1523. doi:10.1016/0140-6736(90)93304-8

Cochi SL, Fleming DW, Hightower AW, et al. Primary invasive Haemophilus influenzae type b disease: a population-based assessment of risk factors. J Pediatr. 1986;108(6):887-896. doi:10.1016/s0022-3476(86)80922-2

Narayanan I, Murthy NS, Prakash K, Gujral VV. Randomised controlled trial of effect of raw and holder pasteurised human milk and of formula supplements on incidence of neonatal infection. Lancet. 1984;2(8412):1111-1113. doi:10.1016/s0140-6736(84)91554-x
 

Narayanan I, Prakash K, Gujral VV. The value of human milk in the prevention of infection in the high-risk low-birth-weight infant. J Pediatr. 1981;99(3):496-498. doi:10.1016/s0022-3476(81)80360-5

Narayanan I, Bala S, Prakash K, Verma RK, Gujral VV. Partial Supplementation with expressed breast-milk for prevention of infection in low-birth-weight infants. Lancet. 1980;2(8194):561-563. doi:10.1016/s0140-6736(80)91994-7

 

 

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